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Cyclopamine tartrate
CAS No. 1178510-81-0
Cyclopamine tartrate( —— )
Catalog No. M10605 CAS No. 1178510-81-0
Cyclopamine tartrate is a natural steroidal alkaloid that inhibits hedgehog (Hh) signaling with IC50 of 46 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameCyclopamine tartrate
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NoteResearch use only, not for human use.
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Brief DescriptionCyclopamine tartrate is a natural steroidal alkaloid that inhibits hedgehog (Hh) signaling with IC50 of 46 nM.
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DescriptionCyclopamine tartrate is a natural steroidal alkaloid that inhibits hedgehog (Hh) signaling with IC50 of 46 nM; inhibits hedgehog-dependent expression of Pax7 with IC50 of 24 nM, blocks the response of neural plate explants to recombinant Shh-N; A useful tool in studying the role of Hh in normal development, and as a potential treatment for certain cancers in which Hh is overexpressed.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayGPCR/G Protein
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TargetHedgehog (Hh)
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RecptorHedgehog (Hh)
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Research Area——
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Indication——
Chemical Information
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CAS Number1178510-81-0
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Formula Weight973.32
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Molecular FormulaC58H88N2O10
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name(3S,3'R,3a'S,6aS,6bS,6'S,7a'R,9R,11aS,11bR)-3',6',10,11b-tetramethyl-1,2,3,3a',4,4',5',6,6a,6b,6',7,7',7a',8,11,11a,11b-octadecahydro-3'H-spiro[benzo[a]fluorene-9,2'-furo[3,2-b]pyridin]-3-ol (2R,3R)-2,3-dihydroxysuccinate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Peukert S, et al. Bioorg Med Chem Lett. 2009 Jan 15;19(2):328-31.
2. Cooper MK, et al. Science. 1998 Jun 5;280(5369):1603-7.
3. Incardona JP, et al. Development. 1998 Sep;125(18):3553-62.
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